whats the back bone of a application enginer for dmg mori

It has been reported that aggregates of amyloid-β (Αβ) peptide associated with Alzheimer's disease behave like an infectious agent when injected into the brain of a mouse model of Alzheimer's disease, showing a pattern of Aβ deposition that depends on both the host and the agent ( 345). As it happens, the latter assertion may not be entirely correct. However, prion diseases were considered unique in that they are transmissible. Prion diseases may present with certain morphological and pathophysiological features that parallel other progressive encephalopathies, such as Alzheimer's and Parkinson's disease ( 12). Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are inevitably fatal neurodegenerative conditions that affect humans and a wide variety of animals. Finally, we discuss potential antiprion therapies and current developments in the realm of prion diagnostics. We describe the clinical and the pathological features of the prion diseases in human and animals, the events occurring during neuroinvasion, and the possible scenarios underlying brain damage. Here we discuss the evolution of the prion concept and how prion-like mechanisms may apply to other protein aggregation diseases. Prion toxicity may arise from the interference with the normal function of PrP C, and therefore, understanding the physiological role of PrP C may help to clarify the mechanism underlying prion diseases. PrP C is necessary for prion replication and for prion-induced neurodegeneration, yet the proximal causes of neuronal injury and death are still poorly understood.

The infectious agent responsible for TSEs is the prion, an abnormally folded and aggregated protein that propagates itself by imposing its conformation onto the cellular prion protein (PrP C) of the host. Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative diseases that affect humans and a large variety of animals.

Whats the back bone of a application enginer for dmg mori